Hyperlipidemia and obesity are one of the major health problems faced in the developing and developed countries. Many plants possess antihyperlipidemic activity and many of them are mentioned in traditional literature, but the specific mechanism and the compound responsible for such activity still remain obscure. MGAT is one of the key enzymes responsible for the synthesis of triglyceride. Anhtocephalus indicus is one of the many plant which is mentioned in traditional literature for the treatment of obesity. The methanolic extract of the plant showed significant inhibition of MGAT enzyme with an IC50 value of 0.00085 μg/ml. Bioactivity guided fractionation of the methanolic extract was carried out to isolate the active compound or fraction responsible for the activity.
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